Research progress on the mechanism of subchondral bone matrix microenvironment changes mediating osteoarthralgia in temporomandibular joint osteoarthritis
10.3969/j.issn.1001-3733.2025.03.018
- VernacularTitle:颞下颌关节骨关节炎软骨下骨基质微环境改变介导骨关节痛相关作用机制研究进展
- Author:
Jialu GAO
1
;
Jianfei YAN
;
Weicheng LU
;
Xiaoxiao HAN
;
Wenpin QIN
;
Haoqing XU
;
Kai JIAO
Author Information
1. 710032 西安,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学口腔医院黏膜病科
- Publication Type:Journal Article
- Keywords:
Temporomandibular joint osteoarthritis;
Subchondral bone;
Bone matrix microenvironment;
Pain
- From:
Journal of Practical Stomatology
2025;41(3):412-416
- CountryChina
- Language:Chinese
-
Abstract:
Temporomandibular joint osteoarthritis is a common chronic degenerative disease,in which joint pain is the most signif-icant symptom,but its pathogenesis is still unclear.Significant subchondral bone lesions can occur in the early stage of osteoarthritis progression,and more and more experimental evidence shows that subchondral bone lesions play an important role in the pain caused by osteoarthritis.Osteoclasts,osteocytes,osteoblasts,endothelial cells,new generating nerves and blood vessels in the sub-chondral bone matrix microenvironment interact with each other and participate in the process of osteoarthritis pain.Therefore,regu-lating the subchondral bone matrix microenvironment is expected to become a new strategy to control joint pain.
