Acute generalized exathematous pustulosis induced by acarbose capsules

VernacularTitle:阿卡波糖胶囊致急性泛发性发疹性脓疱病
Author: Hui XUE ¹ ; Zhen YE ; Jilin WEI ; Xin LYU ; Shuqin ZHU ; Xu DENG ; Ying LI ; Chunguang CHEN ; Cheng CHENG
Author Information

1. 江苏省宿迁市第一人民医院内分泌科，宿迁　223800
Publication Type:Journal Article
Keywords: Acute generalized exathematous pustulosis; Acarbose
From: Adverse Drug Reactions Journal 2021;23(3):152-153
CountryChina
Language:Chinese
Abstract: A 66-year-old male patient with type 2 diabetes mellitus was treated with oral dapagliflozin (10 mg once daily) and pioglitazone hydrochloride and metformin hydrochloride (515 mg twice daily) regularly for more than 5 months and no adverse reactions occurred. Pioglitazone hydrochloride and metformin hydrochloride was changed to acarbose capsules (50 mg thrice daily orally) by himself. Three days later, the patient developed generalized skin itching with fever (at high temperature up to 41.0 ℃), followed by pustules in the size of soybean to broad beans scattering on the whole body. Then acarbose capsules were stopped immediately. After consultation with dermatologists, acute generalized exathematous pustulosis was diagnosed. The patient was treated with dexamethasone for anti-allergy, insulin for management blood sugar, and cefoxitin for anti-infection. On the 4th day after discontinuation of acarbose capsules, the patient′s rash was improved and scab formed at the ulceration site; on the 9th day, the rash subsided.