The value of combined detection of levels of interleukin 22 and 26 in pleural effusion and serum in the diagnosis of tuberculous pleurisy
10.3760/cma.j.cn115455-20240909-00783
- VernacularTitle:胸腔积液、血清中白细胞介素22和26水平联合检测诊断结核性胸膜炎的价值
- Author:
Xiaodan YANG
1
;
Lifeng WANG
1
;
Yalan WEI
1
Author Information
1. 西安高新医院呼吸与危重症医学科，西安 710075
- Publication Type:Journal Article
- Keywords:
Peritonitis, tuberculous;
Pleural effusion;
Serum;
Interleukin-22;
Interleukin-26
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(5):417-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the levels of interleukin-2 (IL-22) and interleukin-26 (IL-26) in pleural effusion and serum in patients with tuberculous pleurisy, and analyze the diagnostic value of their combination for tuberculous pleurisy.Methods:From January 2016 to December 2023, 310 patients with tuberculous pleurisy admitted to Xi′an Hi-tech Hospital were included as the study group, and another 310 patients with non tuberculous pleurisy were regarded as the control group. The pleural effusion and serum samples of hospitalized patients were collected. Serum samples were collected from patients at 2 months after treatment for testing of IL-22 and IL-26 levels. The diagnostic value and correlation of IL-22 and IL-26 levels in pleural effusion and serum were analyzed.Results:Compared with the control group, the levels of pleural effusion and serum IL-26 and IL-22 in the study group were increased: (84.68 ± 12.17) ng/L vs. (69.33 ± 9.82) ng/L, (82.45 ± 11.75) ng/L vs. (39.53 ± 5.66) ng/L and (74.38 ± 10.57) ng/L vs. (53.32 ± 7.54) ng/L, (21.45 ± 3.14) ng/L vs. (14.45 ± 2.05) ng/L, and the differences were statistically significant ( P<0.01). Compared with before treatment, serum IL-26 and IL-22 levels decreased after treatment: (61.66 ± 8.72) ng/L vs. (74.38 ± 10.57) ng/L, (17.38 ± 2.59) ng/L vs. (21.45 ± 3.14) ng/L, and the difference was statistically significant ( P<0.01). The AUC of IL-26 and IL-22 in pleural effusion and serum samples in the diagnosis of tuberculous pleurisy was 0.895, 0.820, 0.929 and 0.893, respectively. The AUC of IL-26 and IL-22 combined detection in pleural effusion and serum samples in the diagnosis of tuberculous pleurisy was 0.964 and 0.970, respectively. Pleural effusion IL-26 was positively correlated with serum IL-26 ( r = 0.733, P<0.01) and positively correlated with pleural effusion IL-22 ( r = 0.544, P<0.01); pleural effusion IL-22 was positively correlated with serum IL-22 ( r = 0.532, P<0.01); serum IL-22 was positively correlated with serum IL-26 ( r = 0.619, P<0.01). Conclusions:The levels of IL-22 and IL-26 in pleural effusion and serum of patients with tuberculous pleurisy are elevated, and the two may jointly participate in the immune regulation of tuberculous pleurisy. It can be used as one of the biochemical diagnostic methods for patients with tuberculous pleurisy.
