The clinical value of laparoscopic-assisted natural orifice specimen extraction surgeryin postoperative patients with stage Ⅲ colorectal cancer based on stress response indexes
10.3760/cma.j.cn115455-20231204-00541
- VernacularTitle:基于应激反应指标探究腹腔镜辅助下经自然腔道取出标本术对Ⅲ期结直肠癌术后患者的临床价值
- Author:
Yunfei SI
1
;
Yun WANG
Author Information
1. 牡丹江市肿瘤医院腹外一科，牡丹江 157000
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Natural orifice specimen extraction surgery;
Laparoscopic radical resection of colorectal cancer;
Stress response;
Postoperative com
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(4):353-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of laparoscopic-assisted natural orifice specimen extraction surgery (NOSES) in postoperative patients with stage Ⅲ colorectal cancer based on stress response indexes.Methods:A total of 86 patients with colorectal cancer treated in Mudanjiang Cancer Hospital and Hongqi Hospital Affiliated to Mudanjiang Medical College from January 2021 to January 2023 were retrospectively selected as the study objects, of which 43 patients underwent conventional laparoscopic radical resection of colorectal cancer (LCR) treatment (control group) and 43 patients underwent NOSES treatment (observation group). The changes of tumor markers, stress response indexes and humoral immunity indexes were compared between the two groups before and aftertreatment, and the incidence of postoperative complications were compared between the two groups.Results:The levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA)19-9, CA242 and CA125 in the two groups were decreased 2 weeks after surgery ( P<0.05), but there were no statistical differences between the two groups ( P>0.05). The level of superoxide dismutase (SOD) in the observation group was higher than that in the control group 3 d after operation: (68.45 ± 8.30) kU/L vs. (59.64 ± 8.18) kU/L; the level of malondialdehyde (MDA) was lower than that in the control group: (8.84 ± 2.03) mmol/L vs. (10.26 ± 2.11)mmol/L, there were statistical differences ( P<0.05). The levels of immunoglobulin (Ig)A, IgM and IgG in the observation group were higher than those in the control group 3 d after operation: (1.59 ± 0.40) g/L vs. (1.33 ± 0.36) g/L, (1.25 ± 0.31) g/L vs. (1.03 ± 0.26) g/L, (8.75 ± 2.12) g/L vs. (6.89 ± 2.05) g/L, there were statistical differences ( P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups ( P>0.05). Conclusions:Laparoscopic-assisted NOSES in the treatment of stage Ⅲ colorectal cancer can effectively improve the level of tumor markers of patients, reduce the stress reaction and immune damage caused by surgery to the patients and ensure the safety.
