Mechanism of mitochondrial dysfunction on immune thrombocytopenia-related fatigue based on the"excessive fire consuming healthy qi"theory
10.3969/j.issn.1006-2157.2025.05.016
- VernacularTitle:基于"壮火食气"理论探讨线粒体功能障碍对免疫性血小板减少症相关乏力的作用机制
- Author:
Yuxin CHENG
1
;
Xiaohua HUANG
;
Diu WEI
;
Wei MA
;
Xinyi CHEN
;
Haiyan LANG
Author Information
1. 北京中医药大学东直门医院 北京 100700;北京中医药大学
- Publication Type:Journal Article
- Keywords:
immune thrombocytopenia;
fatigue;
excessive fire consuming healthy qi;
mitochondrial dysfunction;
invigorating spleen and benefiting qi to promote the production of blood
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(5):703-710
- CountryChina
- Language:Chinese
-
Abstract:
Immune thrombocytopenia(ITP)is an autoimmune disease characterized primarily by bleeding and fatigue.ITP-related fatigue can substantially affect health-related quality of life and has been recognized as a treatment indication in the latest guidelines.However,its pathogenesis remains unclear,and targeted therapies are lacking.This paper explores the theoretical foundation of the"excessive fire consuming healthy qi"theory,linking two key conceptual pairs:"excessive fire"with inflammation and"healthy qi consumption"with mitochondrial dysfunction.Chronic inflammation leads to continuous"qi consumption"and damage to mitochondrial structure and function,ultimately resulting in symptoms of qi deficiency such as tiredness and fatigue.The imbalance between qi and fire,leading to imbalance of yin and yang,is the primary pathogenesis of ITP-related fatigue,with the disease mainly affecting the spleen.Considering the etiology and pathogenesis of ITP,and relative equilibrium of yin-yang,the therapeutic approach of invigorating spleen and benefiting qi to promote the production of blood serves as a core treatment strategy.Previous research has demonstrated the clinical efficacy of Jianpi Yiqi Shexue Formula,consisting of milkvetch root,tangshen,Indian bread,largehead atractylodes rhizome,India madder root,and ass hide glue in treating patients with ITP-related fatigue.Designed to invigorate the spleen and regulate qi and blood,this formula aligns with the pathogenesis of ITP-related fatigue characterized by deficiency of spleen qi and stomach qi.The formula also modulates the expression levels of key proteins and genes involved in mitochondrial energy metabolism and alleviates the immune dysfunction.These findings highlight the potential for further research into the mechanism of ITP-related fatigue,particularly by using inflammation-mediated mitochondrial energy metabolism as a promising entry point.
