Acute liver injury induced by tamsulosin hydrochloride sustained release capsules and Qianliexin capsules (前列欣胶囊)
10.3760/cma.j.cn114015-20200506-00497
- VernacularTitle:联合应用盐酸坦索罗辛缓释胶囊与前列欣胶囊致急性肝损伤
- Author:
Qun LIU
1
;
Wenwen JIN
;
Ning GENG
;
Zhonghua LIN
;
Yongning XIN
Author Information
1. 青岛大学附属青岛市市立医院感染科 266011
- Publication Type:Journal Article
- Keywords:
Chermical and drug induced liver injury;
Tamsulosin;
Qianliexin capsules
- From:
Adverse Drug Reactions Journal
2020;22(8):484-485
- CountryChina
- Language:Chinese
-
Abstract:
A 63-year-old male patient took tamsulosin hydrochloride sustained release capsules 0.2 mg daily and Qianliexin capsules 2 g thrice daily by himself for urinary urgency and urodynia. Twenty-five days later, he developed itchy skin, deep brown urine, nausea, fatigue, and loss of appetite. Laboratory tests showed alanine aminotransferase (ALT) 265 U/L, aspartate aminotransferase (AST) 163 U/L, total bilirubin (TBil) 155.1 μmol/L, direct bilirubin (DBil) 74.7 μmol/L, indirect bilirubin (IBil) 80.4 μmol/L, alkaline phosphatase (ALP) 261 U/L, and gamma-glutamyltransferase (γ-GT) 184 U/L. Liver biopsy showed the cholestatic liver injury. He was diagnosed as acute drug-induced liver injury, which might be related to the above 2 drugs. The above 2 drugs were stopped and oral ursodeoxycholic acid 250 mg thrice daily was given. On day 42 of drug withdrawal, laboratory tests showed ALT 368 U/L, AST 179 U/L,TBil 504.9 μmol/L, DBil 382.8 μmol/L, IBil 122.1 μmol/L, ALP 201 U/L, and γ-GT 58 U/L. On day 91 of drug withdrawal, laboratory tests showed ALT 78 U/L, AST 62 U/L, TBil 138.1 μmol/L, DBil 118.2 μmol/L, IBil 20.2 μmol/L, ALP 140 U/L, and γ-GT 31 U/L. The patient′s liver function returned to normal 135 days after drug withdrawal.
