Evolution law of type 2 diabetes mellitus"pre-disease-disease"and the identification strategy of critical transition based on the dynamical system theory
10.3969/j.issn.1006-2157.2025.05.011
- VernacularTitle:基于动力系统理论的2型糖尿病未病-已病演化规律与临界转变识别策略研究
- Author:
Shiyao WANG
1
;
Kangle SHI
;
Yuefan YU
;
Cong LEI
;
Fangyan YANG
;
Qinggang MENG
Author Information
1. 北京中医药大学中医学院 北京 100029
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
pre-disease;
critical state;
identification of critical transition;
dynamical system
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(5):669-677
- CountryChina
- Language:Chinese
-
Abstract:
Deficiencies remain in the early identification and screening method for type 2 diabetes mellitus(T2DM).Relying solely on blood glucose indicators as diagnostic criteria fails to capture the systematic evolution of glucose metabolism destabilization and does not allow for the identification of the critical transition period preceding the onset of T2DM.In the complex system of the human body,structural and state variables correspond to the traditional Chinese medicine concepts of"zang"and"xiang."These variables determine the landscape of the systemic state changes over time.The pathogenesis of T2DM is characterized by a shift from compensatory insulin secretion to β-cell dysfunction,driven by negative-positive feedback dynamics,ultimately resulting in a marked increase in blood glucose levels.A critical transition exists between glycemic homeostasis and the establishment of T2DM disease homeostasis.Using theoretical approaches such as critical slowing and dynamic network markers in dynamical systems theory,various clinical case data-including four-diagnosis information,multiple biological samples,and histological analysis method-can be leveraged to identify the critical transition key stage from pre-disease to disease of T2DM,facilitating early intervention.This paper aims to develop a dynamic model describing the transition from"glucose homeostasis-glycemic state of instability-steady state of T2DM"by analyzing the mechanism of the complex human system and the dynamic characteristics underlying T2DM onset.This framework aims to enhance early identification method.Establishing this holistic approach offers a novel perspective for the prevention and treatment of T2DM.
