Erythema multiforme-type drug eruption induced by epalrestat
10.3760/cma.j.cn114015-20190423-00382
- VernacularTitle:依帕司他致多形红斑型药疹
- Author:
Xu TIAN
1
;
Hongmei ZHANG
1
;
Lirui SUN
1
;
Qiushi GUO
1
;
Wei ZHOU
1
Author Information
1. 吉林大学第一医院二部药学部，长春 130031
- Publication Type:Journal Article
- Keywords:
Drug eruption;
Erythema multiforme;
Epalrestat
- From:
Adverse Drug Reactions Journal
2020;22(8):486-487
- CountryChina
- Language:Chinese
-
Abstract:
A 56-year-old female patient received epalrestat 50 mg thrice daily orally because of the diagnosis of diabetic peripheral neuropathy. After 3 times of epalrestat treatment that day (about 10 hours after the first medication), the patient developed red papules on the face and patch-like erythema on the head and neck. On day 2 of epalrestat treatment, the rashes were progressively aggravated and the patient was diagnosed with erythema multiforme-type drug eruption. Considering that it might be caused by epalrestat, the drug was replaced by lipoic acid injection and symptomatic treatments with dexamethasone, vitamin C injection, and calcium gluconate injection were given. Three days later, the patient′s allergic symptoms were alleviated. Anti-allergic drugs were phased out gradually while the other drugs were continued. Six days later, the patient had no discomfort and was discharged from the hospital. At 20 days of follow-up, the rashes did not recur.
