Successful treatment of hand-foot syndrome caused by crizotinib with external use of traditional Chinese medicine: report of 2 cases

VernacularTitle:外用中药成功治疗克唑替尼所致手足综合征2例
Author: Yuying PEI ¹ ; Nuo LI ; Liqun JIA ; Yanni LOU
Author Information

1. 中日友好医院中西医结合肿瘤内科，北京　100029（为北京中医药大学硕士研究生　100029）
Publication Type:Journal Article
Keywords: Molecular targeted therapy; Crizotinib; Hand-foot syndrome
From: Adverse Drug Reactions Journal 2020;22(8):481-483
CountryChina
Language:Chinese
Abstract: Two patients (patient 1, a 60-year-old female; patient 2, a 62-year-old male) received oral targeted drug crizotinib (250 mg twice daily and 500 mg once daily, respectively) for anaplastic lymphoma kinase-positive non-small cell lung cancer. Both patients developed skin reactions of their hands after half a year of treatment, which were aggravated as the treatment continued. Symptoms of patient 1 presented as large red patches on the hands, forearms, and neck, with mild epidermis hypertrophy and desquamination, accompanied by obvious tenderness. Symptoms of patient 2 presented as chapped, ulcerated, and erosive skin on the fingertips and palms, accompanied by obvious pain. The 2 patients were given soaking treatment with compound granules of traditional Chinese medicine consisting of raw Astragalus, Carthamus, Radix Arnebiae, Geranium, and Radix Angelicae Sinensis, and their symptoms were obviously improved after 4 and 5 weeks, respectively.