Rhabdomyolysis and multiple organ damage due to sibutramine
10.3760/cma.j.cn114015-20190408-00346
- VernacularTitle:西布曲明致横纹肌溶解症并多器官损伤
- Author:
Xianmin LI
1
;
Fang LIN
1
;
Jingsong MU
1
Author Information
1. 解放军总医院第五医学中心内科重病监护病房，北京 100039
- Publication Type:Journal Article
- Keywords:
Anti-obesity agents;
Sibutramine;
Rhabdomyolysis;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2020;22(8):494-495
- CountryChina
- Language:Chinese
-
Abstract:
A 27-year-old male patient mistakenly took an anti-obesity agent containing sibutramine. Two months later, the patient developed fever and myalgia. Two days later, his above symptoms were aggravated, and unconsciousness, rashes, and oliguria appeared. Laboratory tests showed serum creatinine 748 μmol/L, aspartate aminotransferase 299 U/L, alanine aminotransferase 102 U/L, total bilirubin 101.6 μmol/L, direct bilirubin 85.5 μmol/L, lactate dehydrogenase 3 070 U/L, myoglobin 12 081 μg/L, and creatine kinase 18 517 U/L. Rhabdomyolysis with multisystem injury caused by sibutramine was diagnosed. The anti-obesity agent was discontinued, and continuous renal replacement therapy and symptomatic and supportive treatments such as magnesium isoglycyrrhizinate, acetylcysteine, and terlipressin were given. After 2 weeks, the patient′s symptoms disappeared, the rashes subsided, and the liver and kidney functions and laboratory tests such as creatine kinase and myoglobin returned to normal.
