Epidermolysis bollosa induced by salivae miltiorrhizae, liguspyragine hydrochloride and glucose injection
10.3760/cma.j.cn114015-20190201-00113
- VernacularTitle:参芎葡萄糖注射液致大疱性表皮松解症
- Author:
Jinfeng LI
1
;
Guanghong QU
1
;
Yuan ZHANG
1
Author Information
1. 山东省威海市立医院药剂科 264200
- Publication Type:Journal Article
- Keywords:
Epidermolysis bullosa;
Drugs, Chinese herbal;
Infusions, intravenous;
Salivae miltiorrhizae, liguspyragine hydrochloride and glucose injection
- From:
Adverse Drug Reactions Journal
2020;22(7):422-423
- CountryChina
- Language:Chinese
-
Abstract:
A 75-year-old male patient received an IV infusion of salivae miltiorrhizae, liguspyragine hydrochloride and glucose injection 200 ml once daily for cerebral infarction. No other drugs were used in the same period. About 6 hours after the first administration, the patient developed erythema and blister all over the body, accompanied by obvious itching. Next day, the patient had a fever, blisters of different sizes could be seen on a large area of swollen erythema, some of the blisters were broken, the area of skin lesions was more than 50% of the body surface, and Nikolsky′s sign was positive. Epidermolysis bullosa caused by salivae miltiorrhizae, liguspyragine hydrochloride and glucose injection was considered. The drug was stopped and anti-allergy and anti-infection treatments including methylprednisolone, calcium gluconate, loratadine, and cefazolin sodium were given. Meanwhile, skin care was strengthened. Three days later, the patient′s body temperature returned to normal, the color of erythema became lighter, and the blisters became smaller. Fifteen days later, the patient′s skin injury basically healed.
