Oligohydramnios caused by exposure to losartan during pregnancy
10.3760/cma.j.cn114015-20190930-00791
- VernacularTitle:孕期氯沙坦暴露致羊水过少
- Author:
Chunrong SONG
1
;
Qiang WEI
;
Li ZHANG
;
Yi XU
;
Meifan DUAN
Author Information
1. 四川大学华西第二医院妇产科/出生缺陷与相关妇儿疾病教育部重点实验室，成都 610041；四川省绵阳市四〇四医院妇产科 621000
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Losartan;
Maternal exposure;
Safety
- From:
Adverse Drug Reactions Journal
2020;22(6):377-378
- CountryChina
- Language:Chinese
-
Abstract:
A 32-year-old female patient with nephrotic syndrome got pregnant during treatments with losartan potassium tablets (50 mg once daily), methylprednisolone tablets(12 mg every other day), and dipyridamole tablets(50 mg once daily). She continued these drugs during pregnancy. Ultrasonographic examination at 24 +2 weeks of gestation indicated oligohydramnios, which lasted until 32 +2 weeks of gestation. The amniotic fluid volume ranged 1.1-3.4 cm, and the amniotic fluid indexes were 1.9-6.9 cm. Losartan and methylprednisolone were discontinued, and nifedipine controlled released tablets (30 mg once daily) were given to reduce blood pressure. Amniotic fluid volume gradually increased to normal. At 34 +4 weeks of gestation, her blood pressure rose to 177/113 mmHg. Preeclampsia was diagnosed. She was treated with magnesium sulfate (IV infusion at a speed of 1 g/h), oral nifedipine controlled released tablets (60 mg once daily) and labetalol (200 mg twice daily). Then her blood pressure was 143/82 mmHg and urinary protein detection was positive (++). At 35 +3 weeks of gestation, a baby boy was delivered by cesarean section, with a body length of 43 cm and a weight of 2 200 g. Neonatal Apgar scores at 1 min and 5 min were both 10, and no birth defects were found. During the follow-up to 24 months of age, his growth and development were good, and intellectual development and physical exercise were normal.
