Effect of simultaneous integrated boost IMRT on quality of life in patients with advanced nasopharyngeal carcinoma
10.3969/j.issn.1005-202X.2025.05.004
- VernacularTitle:同步推量调强放疗对晚期鼻咽癌患者生存质量的影响
- Author:
Bin LIU
1
;
Zi CHEN
;
Zhihui HU
;
Yan LI
;
Kun CHEN
Author Information
1. 石家庄市人民医院耳鼻咽喉头颈外科,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
simultaneous integrated boost intensity-modulated radiotherapy;
advanced nasopharyngeal carcinoma;
quality of life
- From:
Chinese Journal of Medical Physics
2025;42(5):577-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and analyze the clinical efficacy of simultaneous integrated boost intensity-modulated radiotherapy(IMRT)and its effect on quality of life in advanced nasopharyngeal carcinoma(NPC)patients.Methods A retrospective analysis was conducted on 62 patients with advanced NPC.Patients were divided into trial group(n=31,simultaneous integrated boost IMRT+chemotherapy)and control group(n=31,conventional IMRT+chemotherapy)according to different treatment regimens.The two groups were compared for objective response rate,disease control rate,recurrence and metastasis rate,long-term survival rate,quality of life score,and incidence of adverse reactions.Results Compared with control group,trial group resulted in higher objective response rate,disease control rate and long-term survival rate,while lower recurrence and metastasis rate,post-therapy quality of life score and incidence of adverse reactions(all P<0.05).Conclusion Patients with advanced NPC show remarkable response to simultaneous integrated boost IMRT which can reduce recurrence and metastasis rate,prolong survival cycle,improve quality of life,and lower incidence of adverse reactions.
