Investigation of intraoperative memory following anesthesia with propofol and sufentanil in patients undergoing painless curettage of the uterine cavity
10.3760/cma.j.cn114015-20181211-01232
- VernacularTitle:丙泊酚联合舒芬太尼麻醉致无痛清宫术患者术中记忆的调查
- Author:
Zhicui ZHANG
1
;
Zhenhua HAN
;
Fang FANG
;
Jinchang LI
;
Ping CUI
;
Min WEI
;
Jing WANG
Author Information
1. 双桥医院麻醉科，北京 100024
- Publication Type:Journal Article
- Keywords:
Propofol;
Sufentanil;
Dilatation and curettage;
Anaesthesia;
Hallucinations
- From:
Adverse Drug Reactions Journal
2020;22(5):295-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the occurrence of intraoperative memory (dream, halluci- nation, and intraoperative awareness) following anesthesia with propofol and sufentanil and analyze its influen- cing factors in patients undergoing painless curettage of the uterine cavity.Methods:The modified Brice questionnaire survey results in patients who underwent painless curettage of the uterine cavity under propofol and sufentanil anesthesia in Shuangqiao Hospital from January 2017 to September 2018 were retrospectively analyzed. The memory of patients from anesthesia induction to consciousness recovery after anesthesia was evaluated, and the incidences of dream, hallucination (including sexual hallucination), and intraoperative awareness were calculated. The possible influencing factors (including age, weight, operation time, initial and total dose of propofol, and total dose of sufentanil) of intraoperative memory after anesthesia with propofol and sufentanil were analyzed using logistic regression method.Results:A total of 2 142 patients were enrolled, aged (28.3±7.4) years and weighing (61.8±10.2) kg, with gestational age of (7.8±1.3) weeks and a median operation time of 5 (3-28) min; the initial dose of propofol was (94.1±20.9) mg, with a total dose of (110.0±39.8) mg; the total dose of sufentanil was (9.9±0.4) μg. Among the 2 142 patients, 1 038 (48.5%) had memory from anesthesia induction to consciousness recovery after anesthesia, 1 019 (98.2%) of which were defined as dreams, 19 (1.8%) as hallucinations, and no one had intraoperative awareness. Eleven of 1 038 patients were defined as having sexual hallucinations and the incidence was 0.5%. There was no significant correlation between the occurrence of intraoperative memory and age, weight, operation time, initial dose and total dose of propofol, and total dose of sufentanil ( P>0.05 for all). Conclusion:The anesthesia of propofol combined with sufentanil may lead to dreams and hallucinations in patients undergoing painless curettage of the uterine cavity, and occurrence of sexual hallucinations should be more paid attention to.
