Torsades de Pointes and Aspen syndrome due to levosimendan
10.3760/cma.j.cn114015-20200103-00005
- VernacularTitle:左西孟旦致尖端扭转型室性心动过速和阿斯综合征
- Author:
Yue SUN
1
;
Jia LIU
;
Qingchi LIAO
Author Information
1. 扬州大学附属医院药剂科 225001
- Publication Type:Journal Article
- Keywords:
Torsades de Pointes;
Hypokalemia;
Levosimendan
- From:
Adverse Drug Reactions Journal
2020;22(4):266-267
- CountryChina
- Language:Chinese
-
Abstract:
A 72-year-old female patient received intravenous injection of furosemide injection and oral metoprolol succinate sustained-release tablets, furosemide tablets, spironolactone tablets, digoxin tablets, and isosorbide mononitrate sustained release tablets for heart failure. Continuous intravenous pumping of levosimendan 12.5 mg dissolved in 0.9% sodium chloride 45 ml at a speed of 1.5 ml/h was additionally given because of her unimproved symptoms of heart failure. After 20 hours of intravenous pumping, the patient developed unconsciousness, no response to voice stimuli, and bilateral mydriasis suddenly. The electrocardiogram monitoring showed heart rate 200 beats per minute, prolonged QT interval, and QTc period 520 ms. The laboratory tests showed serum potassium 3.02 mmol/L. She was diagnosis as Torsades de Pointes and Aspen syndrome, which were considered to be related with levosimendan. Levosimendan was stopped immediately. The treatments such as closed-chest cardiac massage, electric defibrillation, and potassium supplementation were given. Four days later, the reexamining results showed her serum potassium 4.60 mmol/L, heart rate 80 beats per minute, and QTc period 450 ms.
