Acute tubulointerstitial nephritis and glomerulosclerosis induced by mesalazine
10.3760/cma.j.cn114015-20190313-00251
- VernacularTitle:美沙拉嗪致急性小管间质性肾炎与肾小球球性硬化
- Author:
Jianglin WANG
1
;
Xiaocong ZUO
;
Xiaoyun PANG
Author Information
1. 中南大学湘雅三医院药学部，长沙 410013
- Publication Type:Journal Article
- Keywords:
Mesalamine;
Nephritis, interstitial
- From:
Adverse Drug Reactions Journal
2020;22(7):426-427
- CountryChina
- Language:Chinese
-
Abstract:
A 31-year-old female patient took mesalazine 1 g thrice daily orally for colitis gravis. Her serum creatinine (Scr) was 78 μmol/L before medication. Five months later, her blood urea (BUN) was 8.3 mmol/L, Scr was 185 μmol/L, and estimated glomerular filtration rate (eGFR) was 31 ml/(min·1.73m 2). Pathological examination of renal biopsy showed acute tubulointerstitial nephritis and glomerulosclerosis. Kidney injury related to mesalazine was considered. Then the drug was stopped. After 26 days of mesalazine withdrawal, laboratory tests showed BUN 4.0 mmol/L, Scr 130 μmol/L, and eGFR 47 ml/(min·1.73 m 2). Prednisone acetate 30 mg daily was given and the dose was decreased to 15 mg daily 2 months later. Then laboratory tests showed BUN 5.5 mmol/L, Scr 93 μmol/L, and eGFR 71 ml/(min·1.73 m 2).
