Acute laryngeal edema induced by doxorubicin liposome
10.3760/cma.j.cn114015-20190102-00007
- VernacularTitle:多柔比星脂质体致急性喉头水肿
- Author:
Yongjin ZHI
1
;
Fenfen ZHOU
1
;
Mengjing WEN
1
;
Zhengdong WU
1
;
Jianfeng ZHU
1
Author Information
1. 南通大学附属泰州市人民医院血液科 225300
- Publication Type:Journal Article
- Keywords:
Doxorubicin;
Liposomes;
Anaphylaxis;
Laryngeal edema
- From:
Adverse Drug Reactions Journal
2020;22(5):315-316
- CountryChina
- Language:Chinese
-
Abstract:
A 69-year-old male patient with peripheral T-cell lymphoma received chemotherapy with intravenous doxorubicin liposome. In the first chemotherapy cycle, no obvious adverse reactions appeared. In the second chemotherapy cycle, the patient developed transient muscle soreness during the IV infusion of doxorubicin liposome. In the third chemotherapy cycle, dexamethasone and chlorphenamine were given to prevent anaphylaxis before doxorubicin liposome treatment and the infusion rate was controlled in a standardized way. However, at about 20 minutes of infusion, the patient developed nausea and vomiting. The infusion of doxorubicin was stopped immediately and replaced by IV infusion of 0.9% sodium chloride injection 250 ml. Then the patient developed facial numbness, laryngeal pain, neck discomfort, and multiple parts of skin rash with pruritus. The electrocardiogram monitoring showed heart rate 130 times/min, blood pressure 80/50 mmHg, and oxygen saturation 0.98. The patient was given oxygen inhalation and in half-lying position following the doctor′s advice, but the patient developed dyspnea, hoarseness, and slurred speech 20 minutes later. Physical examination showed the patient′s tongue was hypertrophic, his neck was swollen and thickened. Acute laryngeal edema induced by doxorubicin liposome was considered. Intravenous injection of dexamethasone 10 mg, IV infusion of 10% calcium gluconate, and aerosol inhalation of budesonide inhalation aerosol were given immediately and about 3 hours later, the symptoms gradually improved. Two days later, the allergic symptoms disappeared.
