Clinical case analysis of severe lacrimal duct obstruction induced by tegafur-gimeracil-oteracil potassium
10.3760/cma.j.cn114015-20191017-00822
- VernacularTitle:替吉奥致严重泪道阻塞的临床病例分析
- Author:
Fang BAI
1
;
Lihua WANG
1
;
Hai TAO
1
;
Xibin ZHOU
1
;
Peng WANG
1
;
Fei WANG
1
Author Information
1. 解放军总医院第三医学中心眼科泪器病中心
- Publication Type:Journal Article
- Keywords:
Tegafur;
Antineoplastic agents;
Lacrimal apparatus diseases;
Lacrimal duct obstruction
- From:
Adverse Drug Reactions Journal
2020;22(5):300-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics, treatment and prognosis of patients with severe lacrimal duct obstruction caused by tegafur-gimeracil-oteracil potassium (S-1).Methods:The medical records and follow-up data of the surgical inpatients with severe lacrimal duct obstruction caused by S-1 in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from January 2017 to January 2019 were analyzed retrospectively.Results:A total of 12 patients were enrolled in this study, including 7 males and 5 females, aged (53±8) years. The time of oral administration of S-1 was (4.1±1.1) months, and the time from the beginning of administration of S-1 to the onset of epiphora symptoms was (53.3±31.2) days. All the 12 patients had binocular diseases (involving 12 cases, 24 eyes) and obstruction of both upper and lower lacrimal canaliculi (involving 48 lacrimal canaliculi). Among the 48 obstructed lacrimal canaliculi, 45 (93.8%) were severe, and 3 (6.2%) were moderate. The 8 lacrimal points of the upper and lower lacrimal canaliculi in both eyes of the 2 patients were completely atresic. In 12 patients, 16 eyes in 8 patients were complicated with complete obstruction of nasolacrimal ducts and 8 eyes in the other 4 patients were complicated with incomplete obstruction of nasolacrimal ducts. Eight patients underwent laser dacryoplasty combined with bicanalicular intubation assisted by lacrimal canaliculus micro-endoscopy. After taking off the tubes, epiphora was relieved in 5 patients but not improved in the other 3 patients. Two patients underwent retrograde exploration to probe canaliculi transdacryocyst combined with bicanalicular intubation. After taking off the tubes, epiphora was relieved. Two patients underwent retrograde exploration to probe canaliculi transdacryocyst combined with dacryocystorhinostomy. After taking off the tubes, epiphora was improved obviously and only slight epiphora was found.Conclusions:Severe lacrimal duct obstruction caused by S-1 was characterized by extensive multiple obstruction. Appropriate surgical treatment can improve the symptoms of epiphora in some patients.
