Drug fever caused by methimazole
10.3760/cma.j.cn114015-20181206-01216
- VernacularTitle:甲巯咪唑致药物热
- Author:
Xiancai SU
1
;
Mingyuan ZHANG
;
Ting CHEN
;
Xiaozheng LAI
Author Information
1. 福建医科大学附属南平第一医院药学部 353000
- Publication Type:Journal Article
- Keywords:
Methimazole;
Fever
- From:
Adverse Drug Reactions Journal
2020;22(5):327-328
- CountryChina
- Language:Chinese
-
Abstract:
A 45-year-old female patient received oral methimazole and propylthiouracil for hyperthyroidism. The drug was discontinued 2 weeks later due to methimazole-induced agranulocytosis. About 1 month later, the patient was re-given methimazole 10 mg thrice daily according to the doctor′s instructions and advice. She developed high fever and chills about 2 hours after the first administration and half on after the second administration, respectively, with a maximum body temperature of 39.5 ℃. The laboratory tests showed WBC 5.99×10 9/L, neutrophil 0.91, C-reactive protein 2.3 mg/L, and negative bacterial blood culture. Drug fever caused by methimazole was considered. Methimazole was stopped and symptomatic treatment was given. Four and a half hours later, the patient′s body temperature dropped to 36.5 ℃. At 1 year of follow-up, the patient did not take methimazole again, and neither high fever nor chills recurred.
