Thrombocytopenia due to moxifloxacin hydrochloride
10.3760/cma.j.cn114015-20180917-00931
- VernacularTitle:盐酸莫西沙星致血小板减少症
- Author:
Jianbiao WU
1
;
Li YU
Author Information
1. 浙江省天台县人民医院药剂科 317200
- Publication Type:Journal Article
- Keywords:
Moxifloxacin;
Thrombocytopenia
- From:
Adverse Drug Reactions Journal
2020;22(5):311-312
- CountryChina
- Language:Chinese
-
Abstract:
An 83-year-old male patient received moxifloxacin hydrochloride (moxifloxacin) 400 mg once daily orally for acute attack of chronic obstructive pulmonary disease. He developed scattered red rashes, accompanied by itching, on his both lower limbs 5 hours after the first dose. Next day, the rashes involved skin on the trunk, and purpura appeared on the multiple skin below the knees. Laboratory tests showed platelet count (PLT) 1×10 9/L, and thrombocytopenia related to moxifloxacin was considered. Moxi- floxacin was stopped and the treatments including hemostasis, anti-allergy, regulation of immune function, and platelet transfusion were given. On day 2 of drug withdrawal, his PLT was 3×10 9/L, and on day 4 the PLT was 35×10 9/L. He was transferred to a superior hospital and received the therapy including anti-immune response, platelet-raising, and hemostasis for 5 days. Then his PLT increased to 244×10 9/L.
