Hypersensitivity syndrome caused by sulfasalazine
10.3760/cma.j.cn114015-20200210-00099
- VernacularTitle:柳氮磺吡啶致超敏反应综合征
- Author:
Shuifang CHEN
1
;
Yaochang GUO
1
Author Information
1. 厦门市中医院药学部，厦门 361009
- Publication Type:Journal Article
- Keywords:
Sulfasalazine;
Drug hypersensitivity syndrome
- From:
Adverse Drug Reactions Journal
2020;22(12):697-698
- CountryChina
- Language:Chinese
-
Abstract:
A 40-year-old female patient was treated with sulfasalazine 0.75 g thrice daily for spondyloarthritis. On the 20th day of medication, the patient developed skin rash all over the body, which was gradually aggravated and accompanied by fever, lymphadenectasis, and splenomegaly. Laboratory tests revealed the white blood cell count 14.4×10 9/L, the eosinophil count 0.82×10 9/L, the urinary occult blood (+++) , alanine aminotransferase 84 U/L, and aspartate aminotransferase 96 U/L. Drug-induced hypersensitivity syndrome was diagnosed and considered to be related to sulfasalazine. Sulfasalazine was discontinued and intravenous infusions of methylprednisolone combined with human immunoglobulin were given. At the same time, anti-infection, anti-allergy, and liver-protective treatments were given additionally. After 8 days of treatments, the rash began to subside and itching was improved; after 18 days, the rash basically subsided and laboratory tests showed the results returned to normal.
