Severe lower gastrointestinal hemorrhage caused by overdose of aspirin without a doctor′s advice
10.3760/cma.j.cn114015-20200226-00172
- VernacularTitle:自服过量阿司匹林致严重下消化道出血
- Author:
Jieting ZHANG
1
;
Hai YANG
;
Xuemei ZHUANG
;
Di YU
Author Information
1. 青岛市中心医院药学部，青岛 266042
- Publication Type:Journal Article
- Keywords:
Aspirin;
Medication errors;
Gastrointestinal hemorrhage
- From:
Adverse Drug Reactions Journal
2020;22(11):638-639
- CountryChina
- Language:Chinese
-
Abstract:
A 67-year-old female patient took aspirin enteric-coated tablets 100 mg thrice daily orally in order to prevent arteriosclerotic cardiovascular disease without doctor′s advice. After 42 days of medication, the patient developed hematochezia, which was progressively aggravated and finally led to severe hemorrhagic anemia (red blood cell count 1.55×10 12/L, hemoglobin 47 g/L) and decreased blood pressure (58/33 mmHg). On the 4th day of bleeding, exploratory laparotomy was performed and colonic hemorrhage was diagnosed. Ligation of the mesenteric artery was performed and the patient′s bleeding stopped. The patient took aspirin by herself at a daily dose exceeding the recommended dose without assessment of benefits and bleeding risks by professional physicians and developed severe lower gastrointestinal hemorrhage, which led to hospitalization and surgical treatment. It was a grade H medication error.
