Investigation of time limit errors of preparation and delivery for cytotoxic antineoplastic drugs and exploration of improvement strategies
10.3760/cma.j.cn114015-20200115-00048
- VernacularTitle:细胞毒性抗肿瘤药物配送时间错误调查及改进的探索
- Author:
Zhaochao MA
1
;
Yanbin SI
1
;
Xin QING
1
;
Jing YANG
1
;
Li YANG
1
;
Zhigang ZHAO
1
Author Information
1. 首都医科大学附属北京天坛医院药学部，北京 100070
- Publication Type:Journal Article
- Keywords:
Antineoplastic agents;
Infusions, intravenous;
Drug compounding;
Medication errors;
Pharmaceutical services;
Quality improvement;
Pharmacy intravenous admix
- From:
Adverse Drug Reactions Journal
2020;22(9):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore a method to shorten the time for preparation and delivery of cytotoxic antineoplastic drugs in pharmacy intravenous admixture services (PIVAS), so that patients can use drugs in time according to the drug labels.Methods:The circumstances of prolonged preparation and delivery time of cytotoxic antineoplastic drugs prepared in PIVAS in Beijing Tiantan Hospital from October 8 to December 31, 2018 were investigated by the project team, the causes were analyzed, and the improvement strategies were made. The drug preparation and delivery time after the improvement strategies was counted and compared with that before improvement to evaluate the improvement effect.Results:From 8 October to 31 December 2018, a total of 4 156 bags of cytotoxic antineoplastic drugs were prepared and delivered in PIVAS in our hospital and the delivery time of 951 bags need to be paid attention to. Though the recording time was not accurate, it could be determined that the delivery time of at least 4.7% (45/951) of those bags had been extended. After taking the improvement measures of priority review for prescription of cytotoxic antineoplastic drugs, priority preparation, and delivery by special person from 20 January 2020, the delivery time of drugs was shortened from 2.5-4.5 hours to 0.5-4.0 hours, and the incidence of delivery time prolongation decreased to 0.9% (12/1 281).Conclusions:In hospital PIVAS, there was a phenomenon of delivery time prolongation of cytotoxic antineoplastic drugs when the drugs were delivered, which might lead to the storage time of the liquid exceeding the requirements of the drug labels. Priority prescription review and delivery of cytotoxic antineoplastic drugs could effectively shorten the delivery time.
