Ventricular fibrillation caused by successive application of ciprofloxacin and levofloxacin
10.3760/cma.j.cn114015-20191230-01105
- VernacularTitle:环丙沙星和左氧氟沙星先后应用致心室颤动
- Author:
Shubin YAN
1
;
Xiao LIU
;
Yishan BU
Author Information
1. 天津市第一中心医院药学部 300192
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin;
Levofloxacin;
Ventricular fibrillation
- From:
Adverse Drug Reactions Journal
2020;22(9):543-544
- CountryChina
- Language:Chinese
-
Abstract:
An 86-year-old male patient received IV infusions of meropenem (1 g once per 12 hours) combined with ciprofloxacin lactate and sodium chloride injection (200 mg once daily) for pneumonia, respiratory failure, and multidrug resistant Pseudomonas aeruginosa infection suggested by sputum bacterial culture. On the 4th day of treatments, the patient developed a sudden drop in blood pressure, and his pulse could not be measured. ECG monitoring suggested ventricular fibrillation. After the treatments of electric defibrillation and amiodarone injection, his sinus rhythm restored. The next day the patient had another three episodes of ventricular fibrillation. All electrolytes were normal during emergency examination and ECG examination showed that the QT interval was normal. Ciprofloxacin was discontinued and replaced by meropenem combined with fosfomycin, and ventricular fibrillation did not recur. Twenty-six days later, the patient′s pneumonia was aggravated and sputum bacterial culture result showed multidrug resistant Pseudomonas aeruginosa infection, which was sensitive to ciprofloxacin and moderately sensitive to levofloxacin. Then meropenem (the same dosage and usage as before) combined with levofloxacin injection (200 mg once daily) were given. On the fifth day of treatments, the patient developed ventricular fibrillation again and his heart rhythm returned to normal after electric defibrillation and amiodarone treatment. Levofloxacin was discontinued and meropenem combined with fosfomycin were given again. Then ventricular fibrillation did not recur. The patient′s ventricular fibrillation was considered to be possibly related to ciprofloxacin and levofloxacin.
