Ameliorative effects of tea on metabolic disorders in obesity mice induced by high-fat diet
10.3969/j.issn.1672-8467.2025.03.009
- VernacularTitle:茶饮改善高脂饮食诱导的肥胖小鼠的代谢紊乱
- Author:
Chen WANG
1
;
Xiang BAN
;
Jia-xing LIU
;
Si-yao SANG
;
Xue AO
;
Ming-jie SU
;
Bin-wei HU
;
Hui LI
Author Information
1. 复旦大学生命科学学院现代人类学教育部重点实验室 上海 200438
- Publication Type:Journal Article
- Keywords:
tea;
high-fat diet(HFD);
obesity;
insulin resistance;
inflammatory reaction;
oxidative stress;
metabolic disorders;
mouse
- From:
Fudan University Journal of Medical Sciences
2025;52(3):393-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ameliorative effects and mechanisms of six types of tea(green tea,cyan tea,red tea,white tea,black tea and yellow tea)on metabolic disorders in obesity mice induced by high-fat diet(HFD).Methods Four-week-old male C57BL/6J mice were randomly divided into 8 groups with 7 mice per group.An HFD-induced obese mouse model was established,and the mice in control group maintained on standard diet followed by intragastric administration of different teas for 5 weeks.The body weight,liver weight ratio,fasting blood glucose,and lipid profile of the mice were measured to assess glucose and lipid metabolism.Serum inflammatory factors including IL-6,tumor necrosis factor-alpha(TNF-α)and oxidative stress markers[malondialdehyde(MDA)and superoxide dismutase(SOD)were measured.Additionally,liver histopathology and the expression of key glycolipid metabolism-related genes,adenosine monophosphate-activated protein kinase(AMPK)and carnitine palmitoyltransferase 1(CPT-1),were analyzed to explore underlying mechanisms.Results Cyan tea significantly suppressed weight gain,demonstrating superior weight control.White tea markedly reduced fasting blood glucose levels and decreased the area under the curve of oral glucose tolerance test(OGTT)and insulin tolerance test(ITT),indicating synergistic improvements in glucose metabolism and insulin sensitivity.Yellow tea exhibited exceptional anti-inflammatory and antioxidant effects,reducing hepatic IL-6 and MDA while enhancing SOD activity.Green tea activated the lipid oxidation pathway by upregulating AMPK/CPT-1 expression.All kinds of tea significantly attenuated hepatic lipid droplet accumulation.Conclusion All six types of tea alleviated metabolic disorders by reducing hepatic fat content in obesity mice.However,different types of tea exert their unique effects on improving metabolic disorders through differential mechanisms such as glucose metabolism regulation,lipid oxidation,and anti-inflammatory and antioxidant actions.
