Biomedical Progress of Viscoelastic Tunable Composite Hydrogel Based on Dynamic Covalent Bonds
10.16156/j.1004-7220.2024.06.028
- VernacularTitle:基于动态共价键的黏弹性可调复合水凝胶生物医学研究进展
- Author:
Siqi ZHANG
1
;
Yuru ZHOU
1
;
Ran LIU
1
;
Xiaogang WU
1
;
Yanqin WANG
1
;
Weiyi CHEN
1
Author Information
1. 太原理工大学 生物医学工程学院,太原 030024
- Publication Type:Journal Article
- Keywords:
composite hydrogels;
dynamic covalent bonds;
viscoelasticity;
stress relaxation;
extracellular matrix
- From:
Journal of Medical Biomechanics
2024;39(6):1212-1220
- CountryChina
- Language:Chinese
-
Abstract:
Due to good biocompatibility and mechanical properties similar to those of natural biological tissues,hydrogels have been widely used in biomedical fields.With the development of biomechanics,more and more researches have found that the viscoelastic tunable composite hydrogels based on dynamic covalent bonds can better simulate the viscoelastic mechanical properties of biological tissues and natural extracellular matrix over time due to their superior biomechanical properties and stimulus responsiveness.This review summarizes in detail the applications of viscoelastic tunable composite hydrogels based on different types of dynamic covalent bonds(imide bonds,disulfide bonds,borate ester bonds,etc.)in the fields of regulating cell function,affecting tissue regeneration and repair,as well as drug delivery.The challenges and opportunities for future research are also proposed.
