Study on the diagnostic efficacy and influencing factors of quantitative infrapatellar fat pad fat fraction and T2* values using mDixon-Quant technique for knee osteoarthritis
10.3969/j.issn.1002-1671.2025.05.022
- VernacularTitle:mDixon-Quant技术定量髌下脂肪垫脂肪分数、T2*值对膝骨关节炎的诊断效能及其影响因素研究
- Author:
Xinru ZHANG
1
;
Yanjun CHEN
1
;
Xintao ZHANG
1
;
Yiou WANG
1
;
Xiaodong ZHANG
1
Author Information
1. 南方医科大学第三附属医院医学影像科,广东 广州 510631
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
infrapatellar fat pad;
mDixon-Quant;
knee osteoarthritis
- From:
Journal of Practical Radiology
2025;41(5):819-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic efficacy of fat fraction(FF)and T2* values of infrapatellar fat pad(IPFP)based on MR mDixon-Quant technique for knee osteoarthritis(KOA),and to analyze their related influencing factors.Methods A total of 178 knee joints from 114 volunteers were included and underwent knee joints X-ray examination and MR mDixon-Quant sequence scanning.The correlation between FF and T2* values of IPFP with gender,age,body mass index(BMI),and K-L grade was analyzed by Spearman's test and multiple linear regression.Receiver operating characteristic(ROC)curves were plotted to assess the diag-nostic efficacy of FF and T2* values for KOA.Results FF value of IPFP was negatively correlated with age,BMI,and K-L grade(r=-0.470,-0.276,-0.679,P＜0.001),and T2* value was also negatively correlated with age,BMI,and K-L grade(r=-0.291,-0.173,-0.505,P＜0.001).Multiple linear regression analysis results showed that only K-L grade had a statistically significant correlation with FF and T2* values(P＜0.001).ROC curve analysis indicated that the area under the curve(AUC)for diagnosing KOA using the FF and T2* values of IPFP were 0.859 and 0.767,respectively,with sensitivity of 0.878 and 0.841,and specificity of 0.719 and 0.573,respectively.The combined diagnosis had an AUC of 0.855,a sensitivity of 0.625,and a specificity of 0.963,improving the diagnostic specificity for KOA.Conclusion FF and T2* values of IPFP can serve as objective imaging indicators for KOA assessment,and their reduction is correlated with the progress of age,BMI,and K-L grade,of which the K-L grade is an independent influencing factor.The combination of FF and T2 can improve the diagnostic specificity of KOA,and provide a quantitative basis for early KOA detection and severity stratification.
