Immune Cells and the Risk of Coronary Heart Disease:a Mendelian Randomization Study Mediated by Serum Metabolites
10.3969/j.issn.1000-3614.2025.05.010
- VernacularTitle:免疫细胞与冠心病风险——基于血清代谢物介导的孟德尔随机化研究
- Author:
Yun ZHU
1
;
Jiaming WEI
;
Ruifang LIN
;
Yongjun LIU
;
Yue LIU
;
Ya LI
;
Zhihua GUO
Author Information
1. 湖南中医药大学 中医学院,长沙 410208
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
immune cell;
serum metabolite;
mediation analysis;
Mendelian randomization
- From:
Chinese Circulation Journal
2025;40(5):508-515
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:This study aims to explore the causal relationships between immune cells and serum metabolites in the development of coronary heart disease(CHD)using Mendelian randomization(MR)methods.Methods:We conducted a two-sample MR analysis utilizing data from the FinnGen Project's genome-wide association study(GWAS)on CHD,alongside data on metabolites and immune cells from the GWAS catalog.For the identified associated metabolites,we further employed mediation MR methods to evaluate their mediating roles in the influence of immune cells on CHD.Results:The MR analysis indicated that three immune cells(IgD-CD24-%B cell,CD11b on CD14+monocyte,HLA DR on DC)had stable causal relationship with CHD(under the premise of inverse variance weighted[IVW]method P<0.05,both MR-Egger and weighted median methods also showed P<0.05).Furthermore,these immune cells were associated with CHD through four metabolites(N-acetylneuraminic acid levels,the ratio of desmethyltaurine to taurine,X-24801 and X-18779).Conclusions:This study reveals the causal relationships between immune cells and serum metabolites in the pathogenesis of CHD,providing new biomarkers for early prediction and risk assessment of CHD.
