Study on the Hemodynamic Effects of Various Bypass Grafting Techniques for the Left Anterior Descending Artery on the Native Artery and Graft Vessels
10.3969/j.issn.1000-3614.2025.05.008
- VernacularTitle:左前降支不同旁路移植方式对自身及桥血管血液动力学影响的研究
- Author:
Ao HAN
1
;
Gang LIU
;
Tao ZHANG
;
Yi SHI
;
Guangyu ZHU
;
Yonghui LIU
Author Information
1. 中国海洋大学 工程学院,青岛 266404
- Publication Type:Journal Article
- Keywords:
coronary artery;
left anterior descending artery;
coronary artery bypass grafting;
hemodynamics;
computational fluid dynamics
- From:
Chinese Circulation Journal
2025;40(5):494-500
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the hemodynamic impact of different bypass grafting methods on the left anterior descending(LAD)artery using computational fluid dynamics,providing a theoretical basis for optimizing coronary artery bypass grafting.Methods:A patient-specific 3D coronary model was constructed using SimVascular software,including an in-situ internal mammary artery graft(model 1)and three free grafts of varying diameters(model 2:2 mm internal mammary artery free graft;model 3 and model 4:3 mm and 4 mm great saphenous vein free grafts).The hemodynamic parameters of the native artery and grafts were compared among the four bypass grafting models.Results:All four bypass grafting models supply sufficient blood flow for the severely stenosed LAD.LAD flow was slightly lower in the model 1.Free internal mammary artery grafts showed higher flow and wall shear stress.4 mm great saphenous vein free grafts presented with maximum flow but lowest shear stress,3 mm great saphenous vein free grafts offered better hemodynamic stability.Conclusions:Computational fluid dynamics analysis indicates that free internal mammary grafts could provide superior hemodynamics,while larger grafts result in lower shear stress,which might affect long-term graft patency.These findings thus provide experimental evidences useful for optimizing LAD bypass strategies.
