Effects of Subchondral Bone Vascularization on Bone Microstructure in Developmental Hip Dysplasia
10.16156/j.1004-7220.2024.06.009
- VernacularTitle:发育性髋关节发育不良的软骨下骨血管形成对骨显微结构的影响
- Author:
Jiren YAN
1
;
Xiaofu ZHANG
;
Linyang CHU
;
Biao ZHONG
Author Information
1. 上海交通大学医学院附属第六人民医院 骨科,上海 200233
- Publication Type:Journal Article
- Keywords:
developmental dysplasia of the hip(DOH);
mechanical load;
subchondral bone;
angiogenesis;
bone microstructure
- From:
Journal of Medical Biomechanics
2024;39(6):1073-1078
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of an abnormal mechanical load in the developmental dysplasia of the hip(DDH)on the bone microstructure and blood vessels of the subchondral bone,and the correlation between bone microstructure and blood vessels.Methods A newborn rat DDH model was constructed using the swaddling method.Histological staining such as hematoxylin-eosin staining,safranin-fast green staining,and immunohistochemical staining was performed on the articular cartilage and subchondral bone of the femoral head.The microstructure of the subchondral bone was analyzed using microcomputed tomography(micro-CT).Results The DDH rats showed degeneration of the articular cartilage accompanied by deterioration of the microstructure of the subchondral bone,decreased bone formation,and increased vascular formation.The level of vascular formation in the subchondral bone was positively correlated with the degree of deterioration of the bone microstructure.Conclusions An abnormal mechanical load in the DDH causes articular cartilage degeneration,increased vascular formation in the subchondral bone,and subchondral bone microstructure deterioration.The correlation analysis revealed that the abnormal vascular formation in the subchondral bone may be an important factor causing the deterioration of bone microstructure and progression of DDH.This study has provided a new direction for the development of DDH.
