Antimicrobial resistance surveillance in the bacterial strains isolated from pediatric intensive care units in China:results from 2020 to 2022
- VernacularTitle:2020-2022年中国儿童重症监护病房临床分离菌的耐药监测
- Author:
Jing LIU
1
;
Huiyuan YAN
;
Gangfeng YAN
;
Guoping LU
;
Pan FU
;
Chuanqing WANG
;
Danqun JIN
;
Wenjia TONG
;
Chenyu ZHANG
;
Jianli CHEN
;
Yi LIN
;
Jia LEI
;
Yibing CHENG
;
Qunqun ZHANG
;
Kaijie GAO
;
Yuanyuan CHEN
;
Shufang XIAO
;
Juan HE
;
Li JIANG
;
Huimin XU
;
Yuxia LI
;
Hanghai DING
;
Hehe CHEN
;
Yao ZHENG
;
Qunying CHEN
;
Ying WANG
;
Hong REN
;
Chenmei ZHANG
;
Zhenjie CHEN
;
Mingming ZHOU
;
Yucai ZHANG
;
Yiping ZHOU
;
Zhenjiang BAI
;
Saihu HUANG
;
Lili HUANG
;
Weiguo YANG
;
Weike MA
;
Qing MENG
;
Pengwei ZHU
;
Yong LI
;
Yan XU
;
Yi WANG
;
Yanqiang DU
;
Huijun CAI
;
Bizhen ZHU
;
Huixuan SHI
;
Shaoxian HONG
;
Yukun HUANG
;
Meilian HUANG
Author Information
- Publication Type:Journal Article
- Keywords: bacterial isolate; antimicrobial resistance; pediatric intensive care unit
- From: Chinese Journal of Infection and Chemotherapy 2025;25(3):303-311
- CountryChina
- Language:Chinese
- Abstract: Objective This study aimed to investigate the antimicrobial resistance profiles of bacterial strains isolated from pediatric intensive care units(PICU)in China for better antimicrobial therapy.Methods Clinical isolates were collected from 17 institutions,including tertiary care children's hospitals and pediatric department of tertiary general hospitals in China from January 1,2020 to December 31,2022.Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or automated systems.Results were interpreted according to the breakpoints released by the Clinical and Laboratory Standards Institute(CLSI)in 2020.Results A total of 10 688 isolates were collected,including gram-positive organisms(39.2％)and gram-negative organisms(60.8％).The top three organisms were S.aureus(13.6％,1 453/10 688),A.baumannii(10.0％,1 067/10 688),and coagulase-negative Staphylococcus(9.9％,1 058/10 688).Multi-drug resistant organisms(MDROs)were very common in children.The prevalence of methicillin-resistant Staphylococcus aureus(MRSA),carbapenem-resistant Enterobacterales(CRE),carbapenem-resistant E.coli,carbapenem-resistant K.pneumoniae(CRKP),carbapenem-resistant A.baumannii(CRAB),and carbapenem-resistant P.aeruginosa(CRPA)was 41.1％,19.4％,8.8％,30.9％,67.4％,and 28.8％,respectively.Overall,more than 50％of Enterobacteriales isolates were resistant to cephalosporins,while nearly 25％of Enterobacteriales isolates were resistant to carbapenems.MDROs were highly resistant to commonly used antibiotics.More than 80％of CRE and CRAB strains were resistant to all beta-lactam antibiotics.CRE and CRAB showed low resistance rates to tigecycline and polymyxin.CRPA showed lower resistance rates to piperacillin,beta-lactamase inhibitor combinations than the resistance rates to third and fourth generation cephalosporins.All of the Staphylococcus and Enterococcus isolates were susceptible to vancomycin and tigecycline.None of PRSP strains isolated from meningitis and nonmeningitis samples were resistant to rifampicin,vancomycin,or linezolid.The prevalence of β-lactamase-negative ampicillin-resistant(BLNAR)strains was 43.3％in Haemophilus influenzae.Conclusions MDROs were prevalent in PICU.It is necessary to establish an effective multidisciplinary team(MDT)to control the antimicrobial resistance.
