The diagnostic value of quadriceps fat fraction as a quantitative biomarker for patellofemoral arthritis
10.3969/j.issn.1002-1671.2025.05.023
- VernacularTitle:股四头肌脂肪分数作为定量标记物在髌股关节炎诊断中的应用价值
- Author:
Binbin YANG
1
;
Pengxiang LI
1
;
Xinxin LIU
1
;
Xiaowen MA
1
Author Information
1. 西安交通大学附属红会医院磁共振室,陕西 西安 710054
- Publication Type:Journal Article
- Keywords:
IDEAL-IQ;
patellofemoral arthritis;
fat fraction;
quadriceps femoris
- From:
Journal of Practical Radiology
2025;41(5):824-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of quadriceps fat fraction(FF)in the early diagnosis of patellofemoral arthritis(PA).Methods A total of 98 patients were selected for conventional knee MRI examination and IDEAL-IQ sequence imaging.The FFm,FFl and FFt of quadriceps were measured.The patient group[chondromalacia patellae(CMP)(CMP group)and PA group]was compared with normal control(NC)(NC group).The receiver operating characteristic(ROC)curve was applied to assess diag-nostic efficacy.Results FFm,FFl,and FFt in the NC group were significantly lower than those in the patient group(P＜0.001).The FFm and FFl in the PA group were significantly higher than those in the CMP group(P=0.015,P=0.011).Additionally,within both CMP and PA groups,FFl was significantly higher than FFm(P＜0.01).The diagnostic efficacy of FFm was the highest for early PA diagnosis,with an optimal threshold of 8.4％.Conclusion The quadriceps FF can effectively quantify muscle fat infiltration in PA patients,especially in the lateral muscle.An increase in FF value can serve as an early quantitative biomarker for PA,providing sig-nificant reference value for clinical diagnosis and disease progression monitoring.
