Distribution and resistance profiles of bacterial strains isolated from cerebrospinal fluid in hospitals across China:results from the CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET脑脊液临床分离细菌的分布和耐药性变迁
- Author:
Juan MA
1
;
Lixia ZHANG
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Han SHEN
;
Wanqing ZHOU
;
Wenen LIU
;
Yanming LI
;
Yi XIE
;
Mei KANG
;
Dawen GUO
;
Jinying ZHAO
;
Zhidong HU
;
Jin LI
;
Shanmei WANG
;
Yafei CHU
;
Yunsong YU
;
Jie LIN
;
Yingchun XU
;
Xiaojiang ZHANG
;
Jihong LI
;
Bin SHAN
;
Yan DU
;
Ping JI
;
Fengbo ZHANG
;
Chao ZHUO
;
Danhong SU
;
Lianhua WEI
;
Fengmei ZOU
;
Xiaobo MA
;
Yanping ZHENG
;
Yuanhong XU
;
Ying HUANG
;
Yunzhuo CHU
;
Sufei TIAN
;
Hua YU
;
Xiangning HUANG
;
Sufang GUO
;
Xuesong XU
;
Chao YAN
;
Fangfang HU
;
Yan JIN
;
Chunhong SHAO
;
Wei JIA
;
Gang LI
;
Jinsong WU
;
Yuemei LU
;
Fang DONG
;
Zhiyong LÜ
;
Lei ZHU
;
Jinhua MENG
;
Shuping ZHOU
;
Yan ZHOU
;
Chuanqing WANG
;
Pan FU
;
Yunjian HU
;
Xiaoman AI
;
Ziyong SUN
;
Zhongju CHEN
;
Hong ZHANG
;
Chun WANG
;
Yuxing NI
;
Jingyong SUN
;
Kaizhen WEN
;
Yirong ZHANG
;
Ruyi GUO
;
Yan ZHU
;
Jinju DUAN
;
Jianbang KANG
;
Xuefei HU
;
Shifu WANG
;
Yunsheng CHEN
;
Qing MENG
;
Yong ZHAO
;
Ping GONG
;
Ruizhong WANG
;
Hua FANG
;
Jilu SHEN
;
Jiangshan LIU
;
Hongqin GU
;
Jiao FENG
;
Shunhong XUE
;
Bixia YU
;
Wen HE
;
Lin JIANG
;
Longfeng LIAO
;
Chunlei YUE
;
Wenhui HUANG
Author Information
- Publication Type:Journal Article
- Keywords: cerebrospinal fluid; bacterium; antimicrobial resistance surveillance
- From: Chinese Journal of Infection and Chemotherapy 2025;25(3):279-289
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the distribution and antimicrobial resistance profiles of common pathogens isolated from cerebrospinal fluid(CSF)in CHINET program from 2015 to 2021.Methods The bacterial strains isolated from CSF were identified in accordance with clinical microbiology practice standards.Antimicrobial susceptibility test was conducted using Kirby-Bauer method and automated systems per the unified CHINET protocol.Results A total of 14 014 bacterial strains were isolated from CSF samples from 2015 to 2021,including the strains isolated from inpatients(95.3％)and from outpatient and emergency care patients(4.7％).Overall,19.6％of the isolates were from children and 80.4％were from adults.Gram-positive and Gram-negative bacteria accounted for 68.0％and 32.0％,respectively.Coagulase negative Staphylococcus accounted for 73.0％of the total Gram-positive bacterial isolates.The prevalence of MRSA was 38.2％in children and 45.6％in adults.The prevalence of MRCNS was 67.6％in adults and 69.5％in children.A small number of vancomycin-resistant Enterococcus faecium(2.2％)and linezolid-resistant Enterococcus faecalis(3.1％)were isolated from adult patients.The resistance rates of Escherichia coli and Klebsiella pneumoniae to ceftriaxone were 52.2％and 76.4％in children,70.5％and 63.5％in adults.The prevalence of carbapenem-resistant E.coli and K.pneumoniae(CRKP)was 1.3％and 47.7％in children,6.4％and 47.9％in adults.The prevalence of carbapenem-resistant Acinetobacter baumannii(CRAB)and Pseudomonas aeruginosa(CRPA)was 74.0％and 37.1％in children,81.7％and 39.9％in adults.Conclusions The data derived from antimicrobial resistance surveillance are crucial for clinicians to make evidence-based decisions regarding antibiotic therapy.Attention should be paid to the Gram-negative bacteria,especially CRKP and CRAB in central nervous system(CNS)infections.Ongoing antimicrobial resistance surveillance is helpful for optimizing antibiotic use in CNS infections.
