Diagnostic value of multimodality-enhanced CT-based radiomics nomogram for muscle-invasive bladder urothelial carcinoma
10.3969/j.issn.1002-1671.2025.05.016
- VernacularTitle:基于多模态增强CT的影像组学列线图对肌层浸润性膀胱尿路上皮癌的诊断价值
- Author:
Na LI
1
;
Shifeng YANG
;
Fei GAO
;
Hexiang WANG
;
Jia GUO
;
Ximing WANG
Author Information
1. 济宁医学院附属济南市章丘区人民医院影像科,山东 济南 250200
- Publication Type:Journal Article
- Keywords:
computed tomography;
radiomics;
nomogram;
urothelial carcinoma;
muscle-invasive
- From:
Journal of Practical Radiology
2025;41(5):790-794
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of multimodality-enhanced CT-based radiomics nomogram for muscle-inva-sive bladder urothelial carcinoma.Methods A retrospective analysis was performed on the preoperative data of 644 patients with pathologically confirmed bladder urothelial carcinoma from three medical centers.Region of interest(ROI)were drawn on preopera-tive contrast-enhanced CT images,and radiomics features were extracted.Patients from medical center 1 were randomly divided into training set and internal validation set in a 7∶3 ratio,while patients from medical centers 2 and 3 were combined as an external val-idation set.The diagnostic performance of the models was evaluated using receiver operating characteristic(ROC)curve.Results In the external validation set,the area under the curve(AUC)for diagnosing muscle-invasive bladder urothelial carcinoma using the multi-phase fusion radiomics model was 0.861[95％ confidence interval(CI)0.811-0.911].The nomogram constructed by combi-ning the multi-phase fusion radiomics model with clinical factors achieved an AUC of 0.901(95％ CI 0.862-0.939).Conclusion The nomogram combining multimodality-enhanced CT-based radiomics with clinical factors can effectively diagnose muscle-invasive bladder urothelial carcinoma.
