Glycation-oxidation-atherosclerosis Cardiovascular Continuum Should not be Ignored
10.3969/j.issn.1000-3614.2025.05.001
- VernacularTitle:重视"糖化-氧化-动脉硬化"心血管事件链
- Author:
Guangwei LI
1
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 内分泌中心,北京 100037
- Publication Type:Journal Article
- Keywords:
type 2 diabetes;
cardiovascular complications;
arteriosclerosis
- From:
Chinese Circulation Journal
2025;40(5):417-419
- CountryChina
- Language:Chinese
-
Abstract:
Several famous evidence-based clinical trials failed to demonstrate that tight glycaemic control of type 2 diabetes could reduce the risk of macrovascular complications of diabetes.This casts doubt on whether"glucose-lowering therapy remains as a central task in the management of cardiovascular complications in type 2 diabetes".Data from 40-year follow-up of the UK Prospective Diabetes Study(UKPDS)and 30-year follow-up of Da Qing Diabetes Prevention Study showed that cardiovascular diseases complication benefit from the'legacy effect'of early intensive glycaemic control persisted for many years after completion of the initial intervention trial.It reminds us of that early interruption of the'glycation-oxidation-arteriosclerosis'cardiovascular continuum remains an important strategy in the prevention and treatment of cardiovascular disease in type 2 diabetes.
