Distribution and antimicrobial resistance profiles of clinical isolates of Nocardia in Hebei Province
10.16718/j.1009-7708.2025.03.011
- VernacularTitle:河北地区临床分离诺卡菌菌种分布及耐药性监测
- Author:
Hongtao REN
1
;
Dongyan SHI
;
Kuo CHENG
;
Xuerui ZHANG
;
Dandan LIU
;
Qiuxiang LEI
Author Information
1. 邢台市人民医院检验科,河北邢台 054000
- Publication Type:Journal Article
- Keywords:
Nocardia;
antimicrobial susceptibility testing;
trimethoprim-sulfamethoxazole
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(3):320-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to investigate the microbiological characteristics and antimicrobial resistance of Nocardia isolates in Hebei Province during the 9-year period.Methods The medical records of all hospitalized patients from whom Nocardia was isolated from 2015 to 2023 were analyzed retrospectively.The isolates were identified to the species level by amplification and sequencing of 16S rRNA,secA1 and ropB genes of Nocardia.Antimicrobial susceptibility of Nocardia isolates were tested by microbroth dilution method.Results Of the 162 strains of Nocardia,128(79.0％)were isolated from respiratory tract specimens,followed by skin and soft tissue infection(25/162,15.4％).Most of the patients with respiratory tract infection were elderly(＞65 years old).Most of the patients with skin and soft tissue infection were middle-aged and elderly(＞45 years old).Twelve species were identified among the 162 isolates.The most common species were N.cyriacigeorgica(36.4％,59/162),N.farcinica(25.3％,41/162),and N.otitidiscaviarum(9.9％,16/162).The most common Nocardia species isolated from the respiratory tract was N.cyriacigeorgica,followed by N.farcinica.The most common species causing skin and soft tissue infection were N.cyriacigeorgica,N.farcinica and N.brasiliensis.All Nocardia strains were susceptible to linezolid,followed by 98.8％susceptible to amikacin and 98.1％susceptible to trimethoprim-sulfamethoxazole(TMP-SMZ).Conclusions Nocardia is mainly isolated from respiratory tract,skin and soft tissues.N.cyriacigeorgica and N.farcinica are the most prevalent species.TMP-SMZ is the first choice for treatment of nocardiosis.Combination therapy may be appropriate for moderate and severe infections according to the results of antimicrobial susceptibility testing.
