Research progress on structure-activity relationship of TLR7/8 ligands
10.16303/j.cnki.1005-4545.2025.04.30
- VernacularTitle:TLR 7/8配体的构效关系研究进展
- Author:
Chang LIU
1
;
Jianyong LI
1
Author Information
1. 中国农业科学院兰州畜牧与兽药研究所农业农村部兽用药物创制重点实验室/甘肃省新兽药重点实验室,甘肃兰州 730050
- Publication Type:Journal Article
- Keywords:
TLR 7/8;
agonists;
antagonists;
structure-activity relationship
- From:
Chinese Journal of Veterinary Science
2025;45(4):877-888
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptor(TLR)7 and 8 are members of the TLRs family,mainly involved in the recognition of single stranded RNA,activating the host's immune response.TLR7/8 regulators are related to the treatment of various diseases such as antiviral,anti-tumor,and autoimmune dis-eases.The development and application of TLR7/8 ligands still receive widespread attention.Up to now,the reported parent nucleus structures of TLR7/8 ligands include purine,pyrimidine,pterine,imidazoloquinoline,thiazoloquinoline,and quinazoline.This article mainly focuses on the structure-activity relationship of several ligands,such as imidazolo[4,5-c]quinoline,8-oxoadenosine,pyridino[2,3-c]pyrimidine,and indole,in order to provide information for the screening,design,or struc-tural modification of TLR7/8 agonists or inhibitors in the future,and to provide new strategies for the prevention or treatment of animal immunosuppressive diseases.
