Research progress on extracellular vesicles of Mycobacterium tuberculosis
10.12138/j.issn.1671-9638.20245001
- VernacularTitle:结核分枝杆菌细胞外囊泡的研究进展
- Author:
Feng-qian MA
1
;
Zhang-hua QIU
;
Wen-ya DU
;
Yu-mei DAI
;
Li-xian WU
;
Guo-fu WANG
Author Information
1. 大理大学基础医学院微生物学与免疫学教研室,云南大理 671000
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
extracellular vesicles;
immune regulation
- From:
Chinese Journal of Infection Control
2024;23(12):1591-1596
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis(TB)is still a serious threat to global public health,causing millions of people infected ev-ery year.Mycobacterium tuberculosis(MTB)is the main pathogen causing TB.In recent years,MTB extracellular vesicles(MEVs)as important carriers for MTB-secreted Mycobacterium antigens have attracted the attention of re-searchers.MEVs enable MTB to secrete phospholipid,nucleic acid,lipopolysaccharide,and periplasmic component in a centralized protective mode,and interact with the host.Some progress has been made on the study of partial contents of MEVs,but the understanding of their biological mechanisms,functions,and roles in the immune re-sponses during MTB infection is still at its early stages.This article reviews the current progress in the biogenesis of MEVs,their roles in MTB infection and immune responses regulation,and discusses their applications in vaccine development and diagnostic techniques.
