Effects of different blood loss time on liver and kidney function,blood lactic acid andoxidative stress after hemorrhagic shock and resuscitation in dogs
10.16303/j.cnki.1005-4545.2025.04.15
- VernacularTitle:不同失血时间对犬失血性休克复苏后肝肾功能、血乳酸及氧化应激的影响
- Author:
Qianzhen ZHANG
1
;
Tong WU
1
;
Xueyan SUN
1
;
Jingbo SUN
1
;
Feng BIN
1
;
Kui HU
1
Author Information
1. 吉林农业大学动物医学院,吉林长春 130118
- Publication Type:Journal Article
- Keywords:
hemorrhagic shock;
dogs;
oxidative stress;
liver and kidney function;
blood lactic acid
- From:
Chinese Journal of Veterinary Science
2025;45(4):731-737
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effects of different blood loss on liver and kidney function,blood lactic acid levels,and oxidative stress indexes after hemorrhagic shock resuscitation in dogs,10 healthy Chinese rural dogs were randomly divided into 1.5 h blood loss resuscitation group(HSRA group)and 3.5 h blood loss resuscitation group(HSRB group).The changes in liver and kidney function,blood lactic acid,and oxidative stress-related indexes were detected at 2,6,24,48 and 72 h after re-suscitation.The results showed that the liver function indexes of TBIL,ALT,and AST in the HSRB group were higher than those in the HSRA group at each time point after resuscitation.There was no significant change in renal function indexes between the two groups.The level of Lac in the HSRB group was significantly higher than that in the HSRA group at 2 and 6 h after resuscitation.CAT activity in the HSRB group was significantly lower than that in the HSRA group at 2 h after resuscitation.GSH-px activity in the HSRB group was significantly lower than that in the HSRA group at 2,6 and 24 h after resuscitation.SOD activity in the HSRB group was significantly lower than that in the HSRA group at 24 h after resuscitation.MDA content in the HSRB group was sig-nificantly higher than that in the HSRA group at 2,6,24 and 48 h after resuscitation.The results showed that HS could cause liver injury and oxidative stress after resuscitation,and the degree of liver injury and oxidative stress injury in dogs increased with the prolongation of blood loss.
