Review on modulation of host innate immune response by Escherichia coli Nissle 1917 and its components
10.16303/j.cnki.1005-4545.2025.04.27
- VernacularTitle:大肠杆菌Nissle 1917及组分调节宿主先天免疫反应的研究进展
- Author:
Di WANG
1
;
Qi LU
;
Meiqing HAN
;
Yan LI
Author Information
1. 浙江大学动物科学学院,浙江 杭州 310058
- Publication Type:Journal Article
- Keywords:
Nissle 1917;
EcN;
innate immune response;
OMVs;
lipopolysaccharide(LPS);
K5 cap-sule;
flagellum
- From:
Chinese Journal of Veterinary Science
2025;45(4):844-858
- CountryChina
- Language:Chinese
-
Abstract:
The Gram-negative bacteria Escherichia coli Nissle 1917(EcN)is a probiotic that has been widely applied in clinical practice.With its notable tolerance,safety,and antimicrobial proper-ties,EcN demonstrates the capacity to colonize the intestine and establish a symbiotic relationship with the host,thereby balancing the intestinal microbiota.Extensive studies have elucidated the mechanisms through which EcN regulates the host's innate immune response enhancing the host's ability to combat pathogenic invasions.On one hand,EcN strengthens the integrity of the intestinal mucosal barrier by upregulating the expression of tight junction proteins.On the other hand,EcN's diverse array of secreted,and released components,including lipopolysaccharides,K5 capsule,fla-gellum proteins,and fimbria,play roles in modulating the host's innate immune response.These components interact with host cell receptors and modulate the activities of immune cells and cyto-kines production.By consolidating the current understanding of EcN's probiotic properties,this ar-ticle provides a comprehensive overview of the intricate mechanisms underlying EcN-mediated reg-ulation of the host's innate immune response.Such insights offer theoretical support for leveraging EcN's advantages and improving immune function and overall health maintenance in the host.
