Advances in role of IL-18 in differentiation,development and activation of eosinophils
10.3969/j.issn.1000-4718.2024.12.022
- VernacularTitle:IL-18在嗜酸性粒细胞分化发育和活化中作用的研究进展
- Author:
Junling WANG
1
;
Mengmeng ZHAN
;
Fangqiu GU
;
Ling WANG
;
Zhaolong ZHANG
;
Xianghua LIN
;
Siqin WANG
;
Shaoheng HE
Author Information
1. 郑州大学人民医院河南省人民医院过敏反应科,河南 郑州 450003;锦州医科大学附属第一医院变态反应与临床免疫研究中心,辽宁 锦州 121001
- Publication Type:Journal Article
- Keywords:
interleukin-18;
eosinophil;
inflammation
- From:
Chinese Journal of Pathophysiology
2024;40(12):2367-2372
- CountryChina
- Language:Chinese
-
Abstract:
Activated eosinophils are the core effector cells in immune responses.Interleukin-18(IL-18),a classical inflammasome-related cytokine,is reported to induce eosinophil differentiation,development and activation by binding with IL-18 receptor α,and thus promoting inflammation responses.Therefore,a thorough understanding of the role of IL-18 in eosinophil differentiation,development and activation is of great significance for the diagnosis and treat-ment of eosinophil-induced inflammatory diseases,and for the research and development of IL-18-related biological agents.
