Research progress in Toll-like receptor agonist types and applications as adjurants for parasitics vaccine
10.3969/j.issn.1002-2694.2024.00.158
- VernacularTitle:Toll样受体激动剂及其作为寄生虫疫苗佐剂研究进展
- Author:
Dan-ni WANG
1
;
Gui-jie ZHENG
1
;
Yi ZHANG
1
;
Yan-hui HAN
1
;
Song WANG
1
;
Hui-li ZHU
1
Author Information
1. 河南科技学院动物科技学院,新乡 453003
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
agonist;
vaccine;
adjuvant
- From:
Chinese Journal of Zoonoses
2024;40(11):1063-1072
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors(TLRs),key molecules initiating innate immune responses,serve as a bridge linking innate and adaptive immune responses.TLRs are transmembrane receptors expressed probably by natural immune cells,and are di-vided into cell surface and intracellular TLRs.Several studies have indicated that TLR agonists as adjuvants can enhance the im-mune protective effects of vaccines.Because of the complex life history of parasites and the differences in antigen characteristics among species or developmental stages in the same species,the research and development of parasite vaccines is challenging.Therefore,the development of effective and safe new adjuvants is crucial for improving the immune efficacy of parasite vac-cines.This article reviews the types and effects of TLR agonists,as well as their applications as adjuvants for parasitic vac-cines,to provide new ideas for the development of new parasitic vaccine adjuvants.
