Effect of chloroquine on replication and proliferation of porcine hemagglutinating encephalomyelitis virus
10.16303/j.cnki.1005-4545.2025.04.02
- VernacularTitle:氯喹对猪血凝性脑脊髓炎病毒复制增殖的影响
- Author:
Ao ZHANG
1
;
Ruizhao QIU
1
;
Zi LI
1
;
Feng GAO
1
;
Deguang SONG
1
Author Information
1. 吉林大学动物医学学院,吉林长春 130062
- Publication Type:Journal Article
- Keywords:
porcine hemagglutinating encephalomyelitis virus;
CQ;
NF-κB;
inflammatory cytokines
- From:
Chinese Journal of Veterinary Science
2025;45(4):634-639
- CountryChina
- Language:Chinese
-
Abstract:
Porcine hemagglutinating encephalomyelitis virus(PHEV)is highly prevalent and wide-ly distributed,and its harm on pig farming is of great concern,therefore,effective strategies for prevention and control are necessary.In this study,chloroquine(CQ)was selected and its effect and mechanism on replication and proliferation of PHEV were investigated.The results showed that CQ(1-100 mmol/L)inhibits the replication and proliferation of PHEV in a dose-dependent manner and has no cytotoxicity on N2a cells.The production of inflammatory cytokines and activa-tion of NF-κB signaling pathway were both inhibited by CQ concentration at 50 mmol/L in PHEV-infected N2a cells.In conclusion,we confirmed the inhibition of CQ in replication and proliferation of PHEV.It is expected to be applied to the prevention and treatment of PHEV in clinical.
