Progress in role of leucine aminopeptidase 3 in occurrence,diagnosis and treatment of cancer
10.3969/j.issn.1000-4718.2024.12.025
- VernacularTitle:亮氨酸氨基肽酶3在癌症发生及诊治中的研究进展
- Author:
Qiao LIANG
1
;
Liancheng LEI
;
Jing HUANG
Author Information
1. 吉林大学白求恩第一医院检验科,吉林 长春 130000
- Publication Type:Journal Article
- Keywords:
leucine aminopeptidase 3;
malignant tumor;
biomarker
- From:
Chinese Journal of Pathophysiology
2024;40(12):2387-2392
- CountryChina
- Language:Chinese
-
Abstract:
Leucine aminopeptidase 3(LAP3)is an enzyme crucial for protein transformation and metabo-lism,as it catalyzes the hydrolysis of amino terminal leucine residues on protein or peptide substrates.This enzymatic ac-tivity is essential for cell growth and development.Abnormal expression of LAP3 is often linked to various diseases.Re-cent studies have indicated that LAP3 expression is elevated in several types of cancer,including breast cancer,hepatocel-lular carcinoma,ovarian cancer,and glioma.Further research has demonstrated that LAP3 influences the proliferation,migration,and invasion of tumor cells by mediating signaling pathways among cancer cells,epithelial-mesenchymal transi-tion,autophagy,cell cycle,and arginine synthesis and metabolism,thereby promoting the development of malignant tu-mors.Consequently,targeted therapies aimed at LAP3 are emerging as a promising area of research.This review summa-rizes the latest advances related to LAP3,evaluates its clinical significance in the diagnosis and prognosis of malignant tu-mors,and explores its carcinogenic effects and potential molecular mechanisms,aiming to offer new insights for the diag-nosis and treatment of these tumors.
