Role of DNA polymerase δ-interacting protein 2 in diseases
10.3969/j.issn.1000-4718.2024.12.024
- VernacularTitle:DNA聚合酶δ相互作用蛋白2在疾病中的作用
- Author:
Keke WANG
1
;
Bing XIAO
1
;
Jingchao LU
1
Author Information
1. 河北医科大学第二医院心血管内科,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
DNA polymerase δ-interacting protein 2;
reactive oxygen species;
mitochondria
- From:
Chinese Journal of Pathophysiology
2024;40(12):2379-2386
- CountryChina
- Language:Chinese
-
Abstract:
DNA polymerase δ-interacting protein 2(Poldip2)is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase δ and proliferating cell nuclear antigen.It directly binds to NADPH oxidase 4 and plays an important role in reactive oxygen species production and cytoskeletal remodeling.It has been implicated in DNA replication,DNA damage repair,mitochondrial function,extracellular matrix regulation,cell cy-cle progression,focal adhesion turnover,and cell migration.This review summarizes the evidence and potential functions of Poldip2 in diverse diseases,including cardiovascular diseases,respiratory diseases,renal diseases,neurological dis-eases,cancers and endocrine diseases,to explore potential therapeutic targets for related diseases.
