Progress in role of myeloid-derived suppressor cells in acute myeloid leu-kemia

VernacularTitle:髓源性抑制细胞在急性髓系白血病中的研究进展
Author: Di LIU ¹ ; Yan WANG ; Xinyu TANG ; Ruirong XU
Author Information

1. 山东中医药大学第一临床医学院,山东济南 250011
Publication Type:Journal Article
Keywords: acute myeloid leukemia; myeloid-derived suppressor cells; immunotherapy; immune escape
From: Chinese Journal of Pathophysiology 2024;40(12):2373-2378
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia(AML)is a clonal and invasive haematological malignancy originating from primitive myeloid cells of the haematopoietic system.Its incidence is the highest in leukemia,accounting for 58.7%of all cases.The prognosis of relapsed and refractory AML is poor,with a 5-year survival rate of approximately 10%.Im-munotherapy is considered an effective method for the clinical treatment of AML;however,immune escape during treat-ment affects the therapeutic effect.Therefore,solving this immune escape problem is necessary to improve clinical effica-cy.Myeloid-derived suppressor cells(MDSCs)play an important role in the regulation of immune escape,which can damage anti-tumor therapy by mediating the immune escape of AML cells.This article reviews the activation mechanism and im-mune regulation mechanism of MDSCs,and the MDSC-targeting immunotherapy in AML.