Effects of semaglutide on prognosis in patients with diabetes mellitus complicated with unstable angina after percutaneous coronary intervention
10.3969/j.issn.1006-5725.2024.24.013
- VernacularTitle:司美格鲁肽注射液对不稳定型心绞痛合并糖尿病患者冠脉介入术预后的影响
- Author:
Ziming ZHAO
1
;
Qi MA
1
;
Jian CHEN
1
;
Yuan CHEN
1
;
Liuyi CUI
1
;
Yujie ZHAO
1
Author Information
1. 南方医科大学附属河南心血管病医院(郑州市心血管病医院)心血管内科(河南 郑州 450000)
- Publication Type:Journal Article
- Keywords:
semaglutide;
unstable angina;
type 2 diabetes;
percutaneous coronary intervention;
prognosis
- From:
The Journal of Practical Medicine
2024;40(24):3515-3520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of semaglutide on the prognosis in patients with unstable angina complicated with diabetes after percutaneous coronary intervention.Methods A total of 178 patients with unstable angina complicated with diabetes diagnosed in Zhengzhou Cardiovascular Hospital from September 1,2022 to March 31,2023 were included.The patients were divided into a study group(43 patients)and a control group(135 patients)according to whether they received semiglutide or not.Changes in HbA1c,fasting blood glucose,body weight,blood pressure and blood lipid were observed before and after treatment.Baseline data and differences in postoperative adverse cardiovascular events including cardiovascular death,all-cause death,acute myocardial infarction,acute ischemic stroke,re-hospitalization due to unstable angina,and coronary revasculariza-tion were compared between the two groups.Results After 12 weeks of treatment,fasting blood-glucose levels in the study group and the control group were(6.0±0.9),(8.5±1.3)mmol/L,HbA1c levels were(6.5±0.7)%,(7.9±0.5)%,BMI was(22.8±3.0),(25.0±2.4)kg/m2,systolic blood pressure was(135.3±9.7),(141.5±8.3)mmHg,respectively,with significant differences(P＜0.05 for all comparisons).Diastolic blood pressure showed a trend of improvement(84.7±7.7),(86.6±7.7)mmHg,but there was no statistical difference.Conclu-sions For patients with unstable angina complicated with diabetes after percutaneous coronary intervention,the application of semaglutide can effectively control blood glucose,body weight,systolic blood pressure,and reduce the risk of cardiovascular events.
