Exploratory study on the relationship between brain structural network changes and gut microbiota in patients with mild cognitive impairment associated with Parkinson's disease
10.3969/j.issn.1006-5725.2024.24.002
- VernacularTitle:帕金森病轻度认知障碍患者脑结构网络改变与肠道菌群的关系
- Author:
Zihui TIE
1
;
Peikun HE
;
Yanyi LI
;
Qingrui DUAN
;
Kun NIE
;
Lijuan WANG
Author Information
1. 华南理工大学医学院(广东 广州 510006);南方医科大学附属广东省人民医院(广东省医学科学院)神经科、广东省神经科学研究所(广东 广州 510180);广州市神经退行性疾病诊治研究重点实验室(广东 广州 510180)
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
mild cognitive impairment;
brain structural network analysis;
gut microbiota
- From:
The Journal of Practical Medicine
2024;40(24):3438-3445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between brain structural networks and gut micro-biota in patients with mild cognitive impairment associated with Parkinson's disease(PD-MCI),and the impact on cognitive function by neuroimaging and intestinal microbiology techniques.Methods 29 cases of patients with PD-MCI and 17 cases of PD patients with normal cognitive function(PD-NC)were enrolled.MRI T1-weighted and diffusion tensor imaging were collected for graph theory analysis,and fecal samples were analyzed using 16s DNA sequencing.Partial correlation analysis assessed relationships among differential bacteria,structural network prop-erties,and cognitive scale scores,finally followed by mediation effect analysis.Results In PD patients,the abundance of Prevotellaceae,Alloprevotella,and UCG-10 bacteria was positively correlated with language and memory cognitive domains,while the abundance of UCG-010 showed a negative correlation with executive function.Additionally,the gut microbiota also was associated with several distinct brain structural network node characteristics.Mediation analysis indicated that Prevotellaceae's effect on logical memory was mediated by the node degree in the right opercular inferior frontal gyrus(IE=0.074,95%CI:0.21～0.001,P=0.046).Conclusions PD-MCI patients showed distinct gut microbiota and brain network features compared to PD-NC patients.The association and the me-diation analysis of gut microbiota with brain networks and cognitive impairment suggests a role for Prevotellaceae in brain network alterations related to MCI,highlighting the gut-brain axis's potential influence on cognition.
