Research progress of tumor-associated neutrophils in immune checkpoint inhibitors resistance

VernacularTitle:肿瘤相关中性粒细胞在免疫检查点抑制剂耐药中的研究进展
Author: Jing HAN ¹ ; Quanlin GUAN
Author Information

1. 兰州大学第一临床医学院(兰州 730000)
Publication Type:Journal Article
Keywords: Tumor-associated neutrophils; Immune checkpoint inhibitors; Drug resistance
From: Practical Oncology Journal 2024;38(5):349-354
CountryChina
Language:Chinese
Abstract: Cancer is a major disease that seriously endangers human health.In recent years,immune checkpoint inhibitors(ICIs)have changed the paradigm of treatment for various solid tumors.Although the initial treatment effect is significant,the issue of drug resistance in this therapy has gradually become apparent.It is particularly important to have a deep understanding of the mecha-nisms of ICIs resistance.Neutrophils in the tumor microenvironment(TME)play a critical role in the resistance of programmed cell death protein-1(PD-1)and its ligand inhibitors.Thus,remodeling tumor-associated neutrophils(TANs)can not only enhance the anti-tumor immune response,but also contribute to improving patient prognosis.This article aims to explore the potential role of TANs in ICIs resistance and summarize current efforts to overcome ICIs resistance.