Locoregional therapeutic strategies for hepatocellular carcinoma
- VernacularTitle:肝癌局部治疗策略
- Author:
Hua XIANG
1
;
Lin LONG
;
Yongjin ZHANG
;
Jumei ZHOU
;
Yang ZHAO
;
Muzi LI
;
Rengeng LIU
;
Shixiong SHI
;
Rongrong WANG
Author Information
- Publication Type:Journal Article
- Keywords: Liver Neoplasms; Antineoplastic Protocols; Precision Medicine
- From: Journal of Clinical Hepatology 2025;41(8):1497-1503
- CountryChina
- Language:Chinese
- Abstract: The incidence and mortality rates of hepatocellular carcinoma(HCC)remain high in China,and the application of surgical resection is often limited due to the fact that most patients are in the advanced stage at the time of confirmed diagnosis.This article reviews commonly used advanced locoregional therapies for HCC and the advances in mainstream techniques such as local ablation(radiofrequency ablation,microwave ablation,irreversible electroporation,and cryoablation),intravascular intervention(transcatheter arterial chemoembolization,hepatic arterial infusion chemotherapy,and Y90 hepatic arterial infusion chemotherapy),and radiotherapy(CyberKnife,proton therapy,and heavy-ion therapy),and a multidimensional decision-making framework is constructed for HCC locoregional therapy by comparing treatment principles,indications,limitations,and clinical data of these techniques.This article aims to provide evidence-based support for persistent dilemmas in clinical decision-making,promote the role of locoregional therapies in clinical practice,and propose the directions for future research and clinical application.This article also establishes a comprehensive clinical roadmap for HCC locoregional therapy,which helps to address current challenges regarding technique selection and delineate future directions for innovation,in order to reshape the treatment of HCC through technological integration and paradigm innovation.
